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Year : 2021  |  Volume : 8  |  Issue : 1  |  Page : 39-41

Febrile infection-related epilepsy syndrome treated successfully with enteral lorazepam as a substitute for intravenous midazolam as weaning drug

Department of Pediatrics and Pediatric Neurology, Santokba Durlabhji Memorial Hospital, Jaipur, Rajasthan, India

Correspondence Address:
Dr. Vivek Jain
Department of Pediatrics and Pediatric Neurology, Santokba Durlabhji Hospital and Medical Research Institute, Bhawani Singh Marg, Jaipur, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JPCC.JPCC_123_20

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Febrile infection-related epilepsy syndrome (FIRES) is an acute-onset epilepsy syndrome usually refractory to conventional antiepileptics and immunomodulation. Here, we report an adolescent male child whose seizures were refractory to multiple anticonvulsants, high-dose phenobarbitone, and ketogenic diet. He subsequently responded to coma induction with midazolam, though with seizure recurrences following multiple attempts at weaning of midazolam over the next 2½ months. Due to continuing prolonged intensive care stay, we substituted intravenous midazolam for equivalent dose of enteral lorazepam with good seizure control.

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