|Year : 2018 | Volume
| Issue : 2 | Page : 42-46
Acute kidney injury with thrombocytopenia
AV Lalitha1, G Suryanarayana2, S Sumithra3
1 Associate Professor, Head, PICU, India
2 Fellow in PICU, PICU, Division of Pediatric Critical care, St John's Medical college and Hospital, India
3 Assistant Professor, PICU, Division of Pediatric Critical care, St John's Medical college and Hospital, India
|Date of Submission||20-Feb-2018|
|Date of Acceptance||10-Mar-2018|
|Date of Web Publication||30-Apr-2018|
A V Lalitha
Head, PICU St John's Medical college and Hospital
Source of Support: None, Conflict of Interest: None
Pediatric AKI presents with a wide range of clinical manifestations from a minimal elevation in serum creatinine to anuric renal failure, arises from multiple causes and occurs in a variety of clinical settings. The prognosis of AKI is highly dependent on the underlying etiology of the AKI. Thrombocytopenia is one of the most common laboratory findings in the ICU. The causes of acute kidney injury associated with thrombocytopenia are very few. This chapter gives an overview of etiology, incidence, diagnosis, conservative treatment, of various causes of AKI associated with thrombocytopenia in children beyond the newborn period in the context of advances made in this field.
Keywords: Renal Replacement Therapy, Thrombocytopenia, Intensive Care Units, Pediatric, Hemolytic-Uremic Syndrome
|How to cite this article:|
Lalitha A V, Suryanarayana G, Sumithra S. Acute kidney injury with thrombocytopenia. J Pediatr Crit Care 2018;5:42-6
Acute kidney injury (AKI) is a frequent complication in patients admitted to the intensive care unit (ICU) and is associated with high mortality rates, particularly when renal replacement therapy (RRT) is required. Acute renal failure (ARF) is associated with adverse outcomes, especially in children admitted to the pediatric intensive care unit (PICU). AKI is a syndrome comprising multiple clinical conditions, and outcomes are influenced by underlying disease. In a prospective obseravational study on clinical profile of acute kidney injury by Sriram Krishnamurthy et,al. they found the common etiologies were infections, (62.9%), acute glomerulonephritis (7.6%), snake envenomation (5.7%), hemolytic uremic syndrome (3.8%) and congestive cardiac failures (3.8%).
Thrombocytopenia is one of the most common laboratory findings in the ICU. In AKI, however, a low PC has been recognized as a prognostic marker. Moreover, severe thrombocytopenia at the beginning of RRT has been associated with hospital mortality. Sepsis-associated AKI (SA-AKI) is the most common cause of AKI with thrombocytopenia in critically ill patients and an independent predictor of morbidity and mortality.
In this article we have discussed HUS and TTP as causes of AKI associated with thrombocytopenia.
Hemolytic uremic syndrome (HUS)
Introduction - The hemolytic uremic syndrome (HUS) is defined by the simultaneous occurrence of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and acute kidney injury. It is one of the main causes of acute kidney injury and thrombocytopenia in children.
Classification - Traditionally, HUS had been divided into diarrhea-positive and diarrhea-negative HUS. The former, also referred to as typical HUS, primarily resulted from Shiga toxin-producing Escherichia coli (STEC) infections, and less frequently from Shigella dysenteriae type 1 infection. All other causes of HUS were referred to as atypical HUS or assigned to the diarrhea-negative HUS.
Clinical manifestations - After 3-8 days of incubation, the first symptom is watery diarrhea, followed by bloody diarrhea and abdominal cramps. Nausea and vomiting are also present. Fever is less commonly observed. The most important factors as- sociated with HUS evolution are the use of anti-motility agents, antibiotics, bloody diarrhea, leukocytosis, young age and female gender. Recovery is often spontaneous, but 26% of patients develop renal failure, with 3%-5% of deaths.,
Hematological and renal symptoms, including hemolytic anemia, low platelet counts, fragmentocytes, increased lactate dehydrogenase (LDH) and very low haptoglobin levels and various degrees of renal failure may all be present. Other symptoms may arise due to the involvement of other organs such as the brain, pancreas and myocardium.,
Diagnosis - The diagnosis of hemolytic uremic syndrome (HUS) is clinically based on the presence of the classical triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury,
- The MAHA is established by a hemoglobin level less than 8 g/dL with a negative Coomb’s test and a peripheral blood smear demonstrating a large number of schistocytes (up to 10 percent of red cells) and helmet cells
- Thrombocytopenia is characterized by a platelet count below 140,000/mm3 and is usually approximately 40,000/mm3. Despite the low platelet count, there is typically no purpura or active bleeding. The degree of thrombocytopenia is unrelated to the severity of renal dysfunction.
Differential Diagnosis - The differential for hemolytic uremic syndrome (HUS) includes several conditions that may also present with concomitant findings of anemia, thrombocytopenia, and acute kidney injury.
- Acute kidney injury - The severity of renal involvement ranges from hematuria and proteinuria to severe renal failure (usually identified by abnormally elevated serum creatinine and blood urea nitrogen [BUN] levels) and oligoanuria. Most patients have microscopic hematuria on urinalysis, although macroscopic hematuria may be observed.
- Disseminated intravascular coagulation (DIC) is distinguished from HUS by the presence of abnormal coagulation studies, including prolonged prothrombin time and activated partial thromboplastin time, and elevated levels of fibrin degradation products and D-dimer. In general, DIC occurs in pediatric patients who are seriously ill, such as those in septic shock or who have undergone massive tissue injury or breakdown.
- Thrombotic thrombocytopenic purpura (TTP) - described below
- Systemic vasculitis - Patients with vasculitis typically have other systemic symptoms (such as arthralgias and rash) and do not have a prodromal diarrheal illness.
Overview - The initial management of hemolytic uremic syndrome (HUS) is supportive.
The approach is as follows:
- Red blood cell transfusions for anemia when clinically indicated (eg, hemoglobin level reaches 6 to 7 g/dL or hematocrit <18 percent).
- Platelet transfusion for patients who have significant clinical bleeding.
- Appropriate fluid and electrolyte management to maintain adequate intravascular volume and correct/avoid electrolyte abnormalities.
- Stopping nephrotoxic drugs or those that are implicated in the etiology of HUS.
- Initiation of dialysis therapy in patients with symptomatic uremia, azotemia ,severe fluid overload, or electrolyte abnormality that is refractory to medical therapy.
- Provision of adequate nutrition.
The use of other interventions is dependent on the underlying cause of HUS.
Thrombotic thrombocytopenic purpura (TTP)
It is a thrombotic microangiopathy (TMA) similar to HUS, is a rare but life-threatening disease in children, characterized by MAHA, and organ involvement., The brain, heart, and kidneys are likely to be affected and intensive care unit (ICU) management is often required to manage organ dysfunction .
The basic pathology in TTP is the widespread formation ofvon Willebrand factor (vWF)-rich platelet thrombi in the microcirculation leading to multiorgan ischemia (causing renal and/or neurological dysfunction), MHA, and thrombocytopenia.
The historical clinical pentad of fever, thrombocytopenia, MHA, neurological symptoms (range from headache and confusion to stroke, coma, and seizures), and renal insufficiency that used to define TTP appears obsolete, as several cohort studies have clearly demonstrated that these 5 symptoms were present in less than 10% of patients with an acute TTP.
Renal involvement - Proteinuria and hematuria are common in TTP. In contrast, acute renal failure with marked azotemia, fluid overload, hypertension, and need of dialysis, is much less common.
Microangiopathic Hemolytic Anemia (MAHA) is a major diagnostic criterion for TTP and it is defined by the presence of schistocytes in the peripheral smear along with evidence of hemolysis. More than 1% schistocytes, in the absence of other causes of thrombotic angiopathies, is highly suggestive of TTP- HUS
The measurement of ADAMTS 13 is necessary in the work up for TTP but it is not a diagnostic criterion because the levels may be normal in many patients that otherwise have all the features of TTP.
The cornerstone of TTP therapy is PE(Plasma Exchange), which has reduced the mortality in TTP from 90 % to <10%. High-dose plasma infusion may be an alternative treatment for TTP in patients who cannot have early PE—with the caveat that large volumes of plasma may result in fluid overload. Rituximab, corticosteroids, and splenectomy are reserved for refractory cases.
Conclusions: Acute kidney injury (AKI) is characterized by the abrupt failure of the kidneys to regulate water and electrolyte homeostasis. AKI with thrombocytopenia often in critically ill children usually associated with SA-AKI, HUS and rarely TTP. Early recognition and appropriate intervention will help early recovery and reduces progression to chronic renal failure.
Source of Funding - Nil
Conflict of Interest - Nil
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